Inhibitor of the Full-Length Form US3 Functions as a Dominant Negative A Short Isoform of Human Cytomegalovirus
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منابع مشابه
A short isoform of human cytomegalovirus US3 functions as a dominant negative inhibitor of the full-length form.
Human cytomegalovirus encodes four unique short (US) region proteins, each of which is independently sufficient for causing the down-regulation of major histocompatibility complex (MHC) class I molecules on the cell surface. This down-regulation enables infected cells to evade recognition by cytotoxic T lymphocytes (CTLs) but makes them vulnerable to lysis by natural killer (NK) cells, which ly...
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The human cytomegalovirus (HCMV) early glycoprotein products of the US11 and US2 open reading frames cause increased turnover of major histocompatibility complex (MHC) class I heavy chains. Since US2 is homologous to another HCMV gene (US3), we hypothesized that the US3 gene product also may affect MHC class I expression. In cells constitutively expressing the HCMV US3 gene, MHC class I heavy c...
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تاریخ انتشار 2005